Pneumococcal Vaccines
Conjugate and polysaccharide vaccines targeting Streptococcus pneumoniae serotypes
This page catalogs 12 pneumococcal vaccine products spanning US-licensed conjugate and polysaccharide vaccines, European formulations, WHO-prequalified products, and discontinued predecessors. The pneumococcal vaccine landscape has expanded steadily from 7-valent to 23-valent polysaccharide and up to 21-valent conjugate coverage, reflecting ongoing efforts to broaden serotype protection against Streptococcus pneumoniae.
Last updated: April 2026.
Pneumococcal Vaccine Catalog
| Trade Name | Generic Designation | Manufacturer | Vaccine Type | Regulatory Status & Year | Key Notes |
|---|---|---|---|---|---|
| Pneumovax 23 | Pneumococcal polysaccharide vaccine (PPSV23) | Merck | Polysaccharide (23-valent) | FDA Licensed, 1983 | 23 serotypes; adults and high-risk children 2 years and older |
| Prevnar 13 | Pneumococcal 13-valent conjugate vaccine (PCV13) | Pfizer | Conjugate (CRM197) | FDA Licensed, 2010 | Replaced PCV7; pediatric and adult |
| Prevnar 20 | Pneumococcal 20-valent conjugate vaccine (PCV20) | Pfizer | Conjugate (CRM197) | FDA Licensed, 2021 | Broadest Pfizer PCV |
| Vaxneuvance | Pneumococcal 15-valent conjugate vaccine (PCV15) | Merck | Conjugate | FDA Licensed, 2022 | Merck PCV15 |
| CAPVAXIVE | Pneumococcal 21-valent conjugate vaccine (PCV21) | Merck | Conjugate | FDA Licensed, 2024 | Newest; 21 serotypes |
| Prevnar (PCV7) | Pneumococcal 7-valent conjugate vaccine | Pfizer (Wyeth) | Conjugate (CRM197) | FDA Licensed, 2000; Discontinued | First PCV; replaced by PCV13 |
| Synflorix | Pneumococcal 10-valent conjugate vaccine (PCV10) | GSK | Conjugate | WHO Prequalified | Not US-licensed; widely used globally |
| Prevenar 13 | PCV13 (international name) | Pfizer | Conjugate | EMA Authorized | European name for Prevnar 13 |
| Apexxnar | PCV20 (international name) | Pfizer | Conjugate | EMA Authorized | European name for Prevnar 20 |
| Pnu-Imune 23 | Pneumococcal polysaccharide vaccine (PPSV23) | Wyeth-Lederle | Polysaccharide (23-valent) | FDA Licensed; Discontinued | Earlier PPSV23; replaced by Pneumovax 23 |
| Pnu-Imune | Pneumococcal polysaccharide (PPSV) | Wyeth-Lederle | Polysaccharide | Discontinued | Earlier PPSV; Wyeth product |
| Moniarix | Pneumococcal conjugate vaccine | GSK | Conjugate | Licensed (non-US); Discontinued | GSK PCV product |
Sources
Regulatory data sourced from FDA CBER Vaccines Licensed for Use in the United States (March 2026), EMA Medicines database, and WHO Prequalified Vaccines list. Catalog scope informed by Khan, Shaz, The Ultimate Vaccine Timeline.