Conjugate and polysaccharide vaccines
This page catalogs 10 pneumococcal vaccine products. The pneumococcal vaccine landscape has undergone rapid expansion — from the original 7-valent conjugate (Prevnar, 2000) to a 21-valent conjugate (CAPVAXIVE, 2024). The shift from polysaccharide to conjugate technology improved immune response in infants and enabled herd protection through reduced nasopharyngeal carriage.
Last updated: April 2026.
| Trade Name | Generic Designation | Manufacturer | Vaccine Type | Regulatory Status & Year | Key Notes |
|---|---|---|---|---|---|
| Prevnar (PCV7) | Pneumococcal 7-valent conjugate vaccine | Pfizer (Wyeth) | Conjugate (CRM197) | FDA Licensed, 2000; Discontinued | First PCV; replaced by PCV13 |
| Prevnar 13 | Pneumococcal 13-valent conjugate vaccine (PCV13) | Pfizer | Conjugate (CRM197) | FDA Licensed, 2010 | Replaced PCV7; pediatric and adult |
| Prevnar 20 | Pneumococcal 20-valent conjugate vaccine (PCV20) | Pfizer | Conjugate (CRM197) | FDA Licensed, 2021 | Broadest Pfizer PCV |
| Vaxneuvance | Pneumococcal 15-valent conjugate vaccine (PCV15) | Merck | Conjugate | FDA Licensed, 2022 | Merck PCV15 |
| CAPVAXIVE | Pneumococcal 21-valent conjugate vaccine (PCV21) | Merck | Conjugate | FDA Licensed, 2024 | Newest; 21 serotypes |
| Pneumovax 23 | Pneumococcal polysaccharide vaccine (PPSV23) | Merck | Polysaccharide (23-valent) | FDA Licensed, 1983 | 23 serotypes; adults and high-risk children |
| Pnu-Imune 23 | Pneumococcal polysaccharide vaccine (PPSV23) | Wyeth-Lederle | Polysaccharide (23-valent) | Discontinued | Earlier PPSV23; Wyeth product |
| Synflorix | Pneumococcal 10-valent conjugate vaccine (PCV10) | GSK | Conjugate | WHO Prequalified | Not US-licensed; widely used globally |
| Prevenar 13 | PCV13 (international name) | Pfizer | Conjugate | EMA Authorized | European name for Prevnar 13 |
| Apexxnar | PCV20 (international name) | Pfizer | Conjugate | EMA Authorized | European name for Prevnar 20 |
Regulatory data sourced from FDA CBER Vaccines Licensed for Use in the United States (March 2026), EMA Medicines database, and WHO Prequalified Vaccines list. Catalog scope informed by Khan, Shaz, The Ultimate Vaccine Timeline.