Hib Vaccines
Conjugate and polysaccharide vaccines
This page catalogs 14 Haemophilus influenzae type b (Hib) vaccine products. The development of Hib conjugate vaccines in the late 1980s dramatically reduced invasive Hib disease in children — one of the most significant achievements in pediatric vaccinology.
Note: Hib antigens also appear in several combination vaccines. See the Combination Vaccines catalog for products like Pentacel, Vaxelis, and Comvax.
Last updated: April 2026.
Hib Vaccine Catalog
| Trade Name | Generic Designation | Manufacturer | Vaccine Type | Regulatory Status & Year | Key Notes |
|---|---|---|---|---|---|
| HIB-Vax | Hib polysaccharide vaccine | Connaught | Polysaccharide (unconjugated) | FDA Licensed, 1985; Discontinued | First Hib vaccine; unconjugated; poor infant efficacy |
| ProHIBIT | Hib polysaccharide-diphtheria toxoid conjugate | Connaught/Pasteur Mérieux | Conjugate | FDA Licensed, 1987; Discontinued | First Hib conjugate vaccine |
| HibTITER | Hib conjugate vaccine (CRM197 conjugate) | Wyeth-Lederle | Conjugate (HbOC) | FDA Licensed, 1988; Discontinued | Discontinued |
| HIB-IMUNE | Hib conjugate vaccine (PRP-D) | Lederle | Conjugate (PRP-D) | FDA Licensed; Discontinued | Early Hib conjugate |
| PedvaxHIB | Hib conjugate vaccine (meningococcal protein conjugate) | Merck | Conjugate (PRP-OMP) | FDA Licensed, 1989 | Currently US-licensed |
| b-CAPSA-1 | Hib polysaccharide vaccine | Praxis Biologics | Polysaccharide | FDA Licensed; Discontinued | Early unconjugated Hib |
| ActHIB | Hib conjugate vaccine (tetanus toxoid conjugate) | Sanofi Pasteur | Conjugate (PRP-T) | FDA Licensed, 1993 | Currently US-licensed |
| OmniHIB | Hib conjugate vaccine (PRP-T) | SmithKline Beecham | Conjugate (PRP-T) | FDA Licensed; Discontinued | Early PRP-T Hib |
| Hiberix | Hib conjugate vaccine (tetanus toxoid conjugate) | GSK | Conjugate (PRP-T) | FDA Licensed, 2009 | Currently US-licensed |
| Pentacel | DTaP-IPV/Hib combination | Sanofi Pasteur | Combination | FDA Licensed, 2008 | 5-in-1 with Hib |
| Vaxelis | DTaP-IPV-Hib-HepB hexavalent | MSP Vaccine Co | Combination | FDA Licensed, 2018 | 6-in-1 hexavalent |
| Comvax | Hib-HepB combination | Merck | Conjugate + Recombinant | FDA Licensed, 1996; Discontinued | Discontinued |
| TriHIBIT | DTaP/Hib combination | Sanofi Pasteur | Combination | FDA Licensed; Discontinued | Discontinued |
| Quimi-Hib | Hib synthetic conjugate vaccine | Finlay Institute (Cuba) | Synthetic conjugate | Licensed in Cuba | World's first synthetic Hib vaccine |
Sources
Regulatory data sourced from FDA CBER Vaccines Licensed for Use in the United States (March 2026) and published literature. Catalog scope informed by Khan, Shaz, The Ultimate Vaccine Timeline.