Live replicating and non-replicating vaccines
This page catalogs 4 mpox and smallpox vaccine products. Smallpox vaccination has the longest history of any vaccine — dating to Edward Jenner's cowpox inoculation in 1796. The modern portfolio includes both replicating vaccinia (ACAM2000) and non-replicating MVA-based (JYNNEOS) platforms, with JYNNEOS holding dual indication for both smallpox and mpox.
Last updated: April 2026.
| Trade Name | Generic Designation | Manufacturer | Vaccine Type | Regulatory Status & Year | Key Notes |
|---|---|---|---|---|---|
| JYNNEOS / Imvamune | Smallpox and monkeypox vaccine, live non-replicating | Bavarian Nordic | Live MVA (non-replicating) | FDA Licensed, 2019 | Dual indication smallpox/mpox |
| ACAM2000 | Smallpox and mpox (vaccinia) vaccine, live | Emergent BioSolutions | Live vaccinia (replicating) | FDA Licensed, 2007 | Replicating vaccinia; significant adverse event profile |
| Dryvax | Smallpox vaccine (dried calf lymph) | Wyeth | Live vaccinia | FDA Licensed; Discontinued | Historical standard; replaced by ACAM2000 |
| Lancy-Vaxina | Calf lymph smallpox vaccine | Swiss Serum Institute | Live viral (calf lymph) | Historical; Discontinued | Swiss smallpox vaccine; approximately 100-year production run |
Regulatory data sourced from FDA CBER Vaccines Licensed for Use in the United States (March 2026) and historical records. Catalog scope and historical context informed by Khan, Shaz, The Ultimate Vaccine Timeline.