Hepatitis B Vaccines
Plasma-derived, recombinant, and adjuvanted vaccines
This page catalogs 17 standalone hepatitis B vaccine products. Hepatitis B vaccines have one of the longest development histories in the modern vaccine era — from the first plasma-derived vaccine (Heptavax-B, 1981) to the first recombinant vaccine (Recombivax HB, 1986) to modern adjuvanted and multi-antigen formulations. The transition from plasma-derived to recombinant production was a landmark in vaccine manufacturing technology.
Note: Hepatitis B antigens also appear in several combination vaccines. See the Combination Vaccines catalog for products like Pediarix, Vaxelis, Infanrix Hexa, and Twinrix.
Last updated: April 2026.
Hepatitis B Vaccine Catalog
| Trade Name | Generic Designation | Manufacturer | Vaccine Type | Regulatory Status & Year | Key Notes |
|---|---|---|---|---|---|
| Heptavax-B | Plasma-derived hepatitis B vaccine | Merck | Plasma-derived | FDA Licensed, 1981; Discontinued | First HBV vaccine; discontinued 1990 |
| Recombivax HB | Hepatitis B vaccine (recombinant) | Merck | Recombinant | FDA Licensed, 1986 | First recombinant vaccine licensed in US |
| Engerix-B | Hepatitis B vaccine (recombinant) | GSK | Recombinant | FDA Licensed, 1989 | GSK recombinant HBV |
| Heplisav-B | Hepatitis B vaccine (recombinant), adjuvanted | Dynavax | Recombinant + CpG adjuvant | FDA Licensed, 2017 | 2-dose adult schedule; CpG 1018 adjuvant |
| PreHevbrio | Hepatitis B vaccine (recombinant) | VBI Vaccines | Recombinant (3-antigen) | FDA Licensed, 2021 | 3-antigen HBV vaccine |
| HBVaxPro | Hepatitis B vaccine (recombinant) | Merck (MSD) | Recombinant | EMA Authorized | European Merck HBV |
| Shanvac-B | Hepatitis B vaccine (recombinant) | Shantha Biotechnics | Recombinant | WHO Prequalified | Affordable recombinant HBV |
| Euvax B | Hepatitis B vaccine (recombinant) | LG Chem | Recombinant | WHO Prequalified | South Korean product |
| Gene Vac-B | Hepatitis B vaccine (recombinant) | Serum Institute of India | Recombinant | Licensed in India | SII product |
| Heberbiovac HB | Hepatitis B vaccine (recombinant) | Heber Biotec (Cuba) | Recombinant | WHO Prequalified | Cuban recombinant HBV |
| Sci-B-Vac | Hepatitis B vaccine (recombinant, 3-antigen) | VBI Vaccines | Recombinant (3-antigen) | Licensed in Israel/EU | Marketed as PreHevbrio in US |
| Fendrix | Hepatitis B vaccine, adjuvanted (AS04) | GSK | Recombinant + AS04 | EMA Authorized | For hemodialysis patients |
| Hepavax-Gene | Hepatitis B vaccine (recombinant) | Janssen (Korea) | Recombinant | Licensed in Asia | Korean HBV product |
| Revac-B | Hepatitis B vaccine (recombinant) | Bharat Biotech | Recombinant | Licensed in India | Indian HBV |
| GenHevac-B | Hepatitis B vaccine (CHO cell recombinant) | Pasteur Mérieux | Recombinant | Licensed (France); Discontinued | French recombinant HBV |
| Hevac-B | Hepatitis B vaccine (plasma-derived) | Pasteur Vaccins | Plasma-derived | Licensed (France); Discontinued | Early French HBV |
| Hepacare | Hepatitis B vaccine (3-antigen) | Medeva/Acambis | Recombinant (3-antigen) | Licensed (UK); Discontinued | Pre/S1, Pre/S2, S antigens |
Sources
Regulatory data sourced from FDA CBER Vaccines Licensed for Use in the United States (March 2026), EMA Medicines database, WHO Prequalified Vaccines list, and India DCGI records. Catalog scope and historical context informed by Khan, Shaz, The Ultimate Vaccine Timeline.